[ITEM:(158)Divine Ruin] When you need antihealen, it would be exchanged for the polynomial by swapping the position of the gem of focus.
[ITEM:(164)Gem of Isolation] When you want to annoy and slow down the enemy.
[ITEM:(228)Necronomicon] When you're killing really well and you're not dying.
[ITEM:(143)Obsidian Shard] When the enemy team has a lot of magic protection.
[ITEM:(1946)Archmage's Gem] When you want early damage.
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